Balasubramanyam’s association with Hamsalekha began after the latter’s successful venture Premaloka in Kannada. Balasubramanyam sung the most songs for Hamsalekha in Kannada. He received his fourth National Film Award for Best Male Playback Singer for the song “Umandu Ghumandu” from the Kannada film Ganayogi Panchakshari Gavayi (1995), which was a Hindustani classical music-based composition by Hamsalekha.
Balasubrahmanyam recorded three songs for A. R. Rahman in his debut film Roja. He began a long-time association with Rahman since then. Other popular songs include “July Maadham” from Pudhiya Mugam, which also marked the debut of singer Anupama, “Mannoothu Manthayilae” from Kizhakku Cheemayile which was a folk number and he almost sang all songs in the musical love story Duet and “Thanga Thaamarai” from Minsara Kanavu which fetched him the sixth and latest of his National Film Award for Best Male Playback Singer till date.
In May 2020, SPB crooned a song on humanity titled “Bharath Bhoomi” which was composed by Ilaiyaraaja as a tribute to the people such as police, army, doctors, nurses and janitors who have been significantly working amid COVID-19 pandemic. The video song was officially unveiled by Ilaiyaraaja through his official YouTube account on 30 May 2020 in both Tamil and Hindi languages.