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Antibiotics not needed after most sinus surgeries

A randomized controlled trial held by Massachusetts Eye and Ear hospital studied about the difference in infection rates of ‘sinus‘ and discovered that antibiotics increased gastrointestinal side effects in various patients.
Antibiotics are not necessary for patients after most routine endoscopic sinus surgeries despite the common practice to prescribe them, according to a team led by researchers at Massachusetts Eye and Ear.
The findings published in IFAR: International Forum of Allergy & Rhinology shows that patients who underwent endoscopic sinus surgery had no differences in outcomes including symptoms and infections whether they took an antibiotic or placebo after surgery.
The only reported difference in outcomes was in side effects, with patients in the antibiotic group 10 times more likely to report symptoms like diarrhea.
Study’s co-senior author Eric H. Holbrook, MD, director of the Division of Rhinology at Mass Eye and Ear and Associate Professor of Otolaryngology-Head and Neck Surgery at Harvard Medical School said, “For routine sinus surgery, antibiotics are unnecessary and may cause more complications like gastrointestinal side effects.”
The researchers embarked on a randomized placebo-controlled trial in 2013 when they started enrolling patients at Mass Eye and Ear undergoing uncomplicated endoscopic sinus surgery.
Patients without evidence of active infection during surgery were randomized to receive either a one-week regimen of an antibiotic or placebo afterwards.
A total of 77 patients (out of 134 enrolled) who met the study criteria were included in the final analysis: 37 received antibiotics and 40 did not. Patients were examined one week and six weeks after surgery.
Patients in both groups reported improvements in sinus symptoms after surgery, however, there were no statistically significant differences reported in rates of infection nasal symptoms between the two groups.
More than 24 per cent of patients in the antibiotic group reported diarrhea compared to 2.5 per cent in the placebo group.
While previous studies have looked at this issue of the utility of antibiotics after sinus surgery, there had been minimal, mixed data. This is the first study to have utilized a randomized trial to assess antibiotics on a one-week treatment duration on well-validated patient outcomes.
“Our findings suggest that otolaryngologists can rethink the practice of routinely prescribing antibiotics after endoscopic sinus surgery,” said study co-senior author Stacey T. Gray, MD, director of the Sinus Center at Mass Eye and Ear and an Associate Professor of Otolaryngology-Head and Neck Surgery at Harvard Medical School.
“Antibiotics should still be considered when the benefits outweigh the risks, including complex surgical procedures are performed or if the patient is at greater risk for developing an infection,” he added.
More than 250,000 sinus surgeries occur each year for treating chronic sinus infections that don’t respond to other medical treatment. In endoscopic sinus surgery, a scope and surgical tools are inserted into the nose to widen or open the normal drainage pathways that connect the sinuses to the nasal cavity.
It has long been debated whether antibiotics are routinely needed immediately after endoscopic sinus surgery to reduce the risk of postoperative infections and decrease swelling, and optimize patient outcomes.
This study only looked at routine endoscopic sinus surgery and not those that use dissolvable nasal packing, which can be a future area of study.

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